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PGC1α co-activates the transcription of hundreds of genes in the nucleus. Shortly after its discovery, PGC1α was characterized as a mitochondrial biogenesis regulator. Recent work suggests that PGC1α also induces the biosynthesis of the universal electron carrier, NAD+. PGC1α and these downstream effector pathways may inform the interplay of renal health with acute kidney injury (AKI) and chronic kidney disease (CKD).
