Fig. 4.
Tonabersat treatment reduces the loss of retinal function in the bright-light damage model (6 animals per group, 12 eyes analyzed). Representative electroretinogram (ERG) waveforms for light intensities ranging from –3.9 to 2.1 log cd.s/m2 of sham-treated ?? (LD) and tonabersat-treated animals in a light-damaged rat retina model. Tonabersat leads to significantly improved a-wave amplitude compared with (A) sham-treated and (B) b-wave amplitude compared with sham-treated (assessed at 2 weeks). (C) Rod PIII amplitude, (D) rod PII amplitude, and cone PII amplitude in the ERG analysis are all improved after tonabersat treatment compared with sham treatment, with improvement increasing over time. *p < 0.05, ** p < 0.01, ***p < 0.001, ****p < 0.0001