Fig. 4.

(a) Forced swimming test (FST). Bars indicate the immobility time, expressed in seconds, in the FST in Wistar Albino Glaxo/Rijswijk (WAG/Rij; n = 6 per group) rats at 6 and 10 months of age following an early long-term treatment (ELTT; started at P30 and lasting 17 weeks) with fingolimod at 1 mg/kg/day (Fing.). *Significantly different (p < 0.05) from age-matched control rats (CTRL). (b) Elevated plus maze (EPM). Bars indicate the time spent in open arms, expressed in seconds, in the EPM in WAG/Rij (n = 6 per group) rats at 6 and 10 months of age following an ELTT with fingolimod at 1 mg/kg/day (Fing.). *Significantly different (p < 0.05) from age-matched control rats (CTRL). (c) Passive avoidance test. Bars indicate the time taken to enter the dark chamber. *Significantly different (p < 0.05) from age-matched fingolimod-treated rats; #Significantly different (p < 0.05) from age-matched control (untreated) WAG/Rij rats. Data are means ± SEM