Table 4.
Outcome measurements before and after treatment
| Outcome measurements | n | Before infusion | After infusion | % of patients improved | Paired t test (1-sided) | |
|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | t | p-value | |||
| MMSE | 6 | 27.3 ± 2.3 | 28.7 ± 0.8 | 67 | 1.87 | 0.06 |
| BDS-2 | 6 | 12.7 ± 3.1 | 15.3 ± 3.8 | 100 | 3.51 | 0.009 |
| WMS-IV Auditory Memory | 6 | 92.5 ± 8.4 | 94.2 ± 11.2 | 50 | 0.62 | 0.28 |
| WMS-IV Visual Memory | 5 | 83.2 ± 9.3 | 89.6 ± 14.4 | 80 | 1.31 | 0.13 |
| WMS-IV Immediate Memory | 5 | 88.6 ± 8.6 | 93.0 ± 11.3 | 80 | 1.43 | 0.11 |
| WMS-IV Delayed Memory | 5 | 88.2 ± 8.4 | 91.2 ± 8.5 | 80 | –0.67 | 0.73 |
| CVLT-II | 6 | 34.0 ± 7.5 | 33.5 ± 6.3 | 33 | –0.28 | 0.61 |
| COWAT | 6 | 26.2 ± 6.7 | 26.2 ± 4.0 | 33 | 0 | 0.50 |
| Beck Anxiety Inventory | 4 | 7.0 ± 7.4 | 4.5 ± 4.1 | 50 | –1.35 | 0.14 |
| SCL-90 Global Severity Index | 4 | 55.8 ± 14.5 | 51.3 ± 7.8 | 75 | –0.78 | 0.25 |
| CANTAB OTS PSFC | 5 | 6.60 ± 1.52 | 7.17 ± 2.14 | 60 | 2.06 | 0.054 |
| CANTAB OTS MLFC (s) | 5 | 52 ± 24.9 | 55.9 ± 41.9 | 60 | 0.42 | 0.65 |
| CANTAB PAL Total Errors (Adj.) | 6 | 76.5 ± 44.2 | 58.2 ± 38.8 | 83 | –2.15 | 0.042 |
| CANTAB SWM Total Errors | 6 | 63.8 ± 17.2 | 66.5 ± 6.7 | 50 | 0.31 | 0.62 |
| CATSYS DTD TI, right hand (m/s) | 6 | 0.87 ± 0.49 | 0.79 ± 0.59 | 50 | –1.08 | 0.16 |
| CATSYS DTD TI, left hand (m/s) | 6 | 0.74 ± 0.29 | 0.65 ± 0.26 | 67 | –1.08 | 0.17 |
| CATSYS PS EO, 30 sec (mm2) | 4 | 10.1 ± 0.81 | 16.0 ± 13.6 | 50 | 1.00 | 0.81 |
| Hippocampus (cm3) | 5 | 5.87 ± 1.00 | 5.84 ± 1.18 | 40 | –0.28 | 0.60 |
| Amygdala (cm3) | 5 | 3.13 ± 0.35 | 3.14 ± 0.36 | 40 | 0.17 | 0.44 |
| Subcortical HV (cm3) | 5 | 48.9 ± 29.2 | 52.8 ± 24.5 | 40 | 0.79 | 0.76 |
| Corpus callosum (cm3) | 5 | 22.1 ± 2.6 | 21.2 ± 3.6 | 20 | –1.77 | 0.93 |
| Corpus callosum HV (cm3) | 5 | 5.9 ± 2.6 | 5.6 ± 2.3 | 40 | –0.48 | 0.33 |
| Corpus callosum FA | 5 | 0.53 ± 0.05 | 0.54 ± 0.05 | 60 | 0.94 | 0.20 |
| Corpus callosum MD (μm2/ms) | 5 | 1.03 ± 0.12 | 1.04 ± 0.09 | 60 | 0.21 | 0.58 |
| N4 Repetition (μV) | 4 | 0.38 ± 0.95 | -1.63 ± 0.14 | 100 | –4.03 | 0.014 |
Magnetic resonance imaging measurements before infusion included only the last visits before infusion. Bold values indicated significance (i.e., p < 0.05)
MMSE = Mini Mental Status Exam; BDS-2 = Behavioral Dyscontrol Scale; WMS-IV = Weschler Memory Scale Fourth Edition; CVLT-II = California Verbal Learning Test; COWAT = Controlled Oral Word Association Test; SCL-90-R = Symptom Checklist-90-Revised; CANTAB = Cambridge Neuropsychological Test Automated Battery; CANTAB OTS = CANTAB One Touch Stockings; CANTAB OTS PSFC = CANTAB OTS problem solved on first choice; CANTAB OTS MLFC = CANTAB OTS mean latency to first choice; CANTAB PAL = CANTAB Paired Association Learning; CANTAB SWM = CANTAB Spatial Working Memory; CATSYS DTD TI = CATSYS Dot-to-Dot Tremor Intensity; CATSYS PS EO = CATSYS Postural Sway Eyes Open; HV = hyperintensity volume; FA = fractional anisotropy; MD = mean diffusivity