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Remyelination. Oligodendrocyte precursor cells (OPCs) undergo maturation to oligodendrocytes, which then wrap myelin around demyelinated axons. At each step, the remyelination process may be promoted or inhibited by intrinsic and extrinsic signals or by environmental cues (adapted from [40] and [107]). NSC = neural stem cell; OPC = Oligodendrocyte precursor cell; OL = Oligodendrocyte; PSA-NCAM = polysialylated neural cell adhesion molecule; MYRF = Myelin Regulatory Factor
