Table 3.

Median (95% CI) ACTH response to insulin tolerance test (ITT)

ACTH response to ITT (pg/mL)	OTS athletes (OTS) (n = 14)	Healthy athletes (ATL) (n = 25)	Non-active subjects (NCS) (n = 12)	p
Basal	19.6 (11.4–32.9)	18.7 (6.5–37.8)	21.4 (8.7–37.8)	n/s
During hypoglycemia	28.2 (8.4–238.9)	57.8 (7.3–229.5)	29.5 (14.8–191.7)	n/s
30′ after hypoglycemia	30.3**** (9.8–93.7)	59.9 (22.1–195.7)	51.4 (22.7–137.5)	0.006
Absolute increase	9.7**** (−14.4–64.4)	45.1 (22.1–195.7)	38.0 (0.5–108.8)	0.004
Percentage increase (%)	52.2	266.2	200.4	– n/a

Differences between OTS and ATL: ****p < 0.001

Level of significance = p < 0.05

CI confidence interval; n/s = non significant; n/a = non appliable