Table 6.

Proposed cutoffs for overtraining syndrome

	Suggested cutoffs	Practical application
Salivary cortisol (ng/dL) 30 min after awakening	> 530 ng/dL	Highly predictable of exclusion of OTS (93.9%).
	370 ng/dL	Highly accurate (80%), but unable to help diagnosis OTS
Serum cortisol (μg/dL) 30 min after hypoglycemia in ITT	> 20.5 μg/dL	High negative predictive value for OTS (100%)
	> 17.0 μg/dL	High positive predictive value for OTS, although not specific (28.6%)
	19.1 μg/dL	High accuracy (84.6%), but not precise for confirmation or exclusion of OTS
Cortisol increase during ITT (μg/dL)	> 9.5 μg/dL	100% specific to exclude OTS
Plasma ACTH (pg/mL) 30 min after hypoglycemia in ITT	> 106 pg/mL	High negative predictive value (92.9%) and highly accurate (80%)
ACTH increase during ITT (pg/mL)	< 35 pg/mL	80% accurate to distinguish OTS from ATL