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Antihyperglycemic activity profile of title compounds thiazolidine-2,4-dione derivatives
| Compounds | Antihyperglycemic activity, SLM | PPARc | |
|---|---|---|---|
| 10 nmol | 1000 nmol | ||
| 28 | − 22.1 | 9 | 9 |
| 29 | − 22.2 | 7 | 8 |
| 30 | − 15.8 | – | – |
| 31 | + 9.00 | – | – |
| 32 | − 26.7 | 10 | 12 |
| 33 | − 12.3 | 9 | 11 |
| 34 | − 12.7 | 8 | 10 |
| 35 | − 4.1 | – | – |
| 36 | − 26.8 | – | – |
| Rosiglitazone | 11.6 | 92 | 248 |
| Metformin | 34.1 | – | – |
PPAR c proxisome proliferator activated receptor
