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. 2017 Dec 4;4:219. doi: 10.3389/fmed.2017.00219

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Copyright © 2017 Seltsam.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The THERAFLEX ultraviolet (UV)-Platelets pathogen inactivation system uses UVC light to induce irreversible damage to the nucleic acids of viruses, bacteria, fungi, protozoa, and leukocytes. Intense agitation of the platelet bag during UVC illumination results in efficient mixing, ensuring the uniform treatment of all blood compartments (A). For the illumination step of this simple and rapid procedure, platelet units are placed in the irradiation device for a period of less than 1 min (B). Afterward, the pathogen-reduced platelet product can be used for transfusion.