Table 1.

Characteristics and availability of relevant patient-reported outcome measures for disease activity and QoL impairment in HAE.

	HAE-AS	AAS	HAE-QoL	AE-QoL
Number of items (questions)	12 (once)	1–6 (everyday)	25 (once)	17 (once)
Recall period	6 months	1 day	6 months	4 weeks
Applicable in HAE 1/2	+	+	+	+
Applicable in other forms of recurrent angioedema	−	+	−	+
Assessment	Retrospective	Prospective	Retrospective	Retrospective
High level of patient compliance required	−	+	−	−
Clinical important difference published	−	+	−	+
Cost-free use in routine patient management and investigator-initiated clinical research	+	+	+	+
Different language versions availablea	American-English, Spanish	American-English, Azeri, Canadian-English, Canadian-French, Danish, Dutch, French, German, Greek, Hebrew, Hungarian, Italian, Japanese, Macedonian, Mexican-Spanish, Polish, Portuguese, Romanian, Russian, Slovakian, Spanish, Swedish, Turkish	Argentinien-Spanish, Austrian-German, Brazilian-Portuguese, Canadian-English, Canadian-French, Danish, French, German, Greek, Hebrew, Hungarian, Italian, Macedonian Mandarin-Chinese, Polish, Romanian, Spanish, US-English, UK-English	American-English, Azeri, Canadian-English, Canadian-French, Danish, Dutch, French, German, Greek, Hebrew, Hungarian, Italian, Japanese, Jordan-Arabic, Macedonian, Mexican-Spanish, Polish, Portuguese, Puerto Rican-Spanish, Romanian, Russian, Slovakian, Spanish, Swedish, Turkish

AAS, angioedema activity score; AE-QoL, angioedema quality of life questionnaire; HAE-AS, hereditary angioedema activity score; HAE-QoL, hereditary angioedema quality of life questionnaire.

^aAdditional language versions of the HAE-AS and HAE-QoL (check www.idipaz.es for updates) and the AAS and AE-QoL (check www.moxie-gmbh.de for updates) are in preparation.