Table 2.
Differences in the genotypes and alleles of the RAGE gene six variants and their risk prediction for type 2 diabetes mellitus in primary hypertensive patients.
| Variants | Region | Genotype or allele | Cases (n = 1252) | Controls (n = 947) | P | Genetic model | OR; 95% CI; P | ||
|---|---|---|---|---|---|---|---|---|---|
| Count | Percent | Count | Percent | ||||||
| −429T > C (rs1800625) | Promoter | TT | 688 | 54.95% | 533 | 56.28% | <0.001 | Additive model | 1.35; 1.03–1.76; 0.029 |
| TC | 398 | 31.79% | 343 | 36.22% | Dominant model | 1.21; 0.83–1.78; 0.318 | |||
| CC | 166 | 13.26% | 71 | 7.50% | Recessive model | 1.76; 1.28–2.41; 0.001 | |||
| C (minor) | 730 | 29.15% | 485 | 25.61% | 0.009 | ||||
| −374T > A (rs1800624) | Promoter | TT | 690 | 55.11% | 551 | 58.18% | 0.027 | Additive model | 1.35; 1.03–1.79; 0.032 |
| TA | 441 | 35.22% | 334 | 35.27% | Dominant model | 1.29; 0.88–1.89; 0.184 | |||
| AA | 121 | 9.66% | 62 | 6.55% | Recessive model | 1.44; 1.02–2.04; 0.040 | |||
| A (minor) | 683 | 27.28% | 458 | 24.18% | 0.020 | ||||
| I/D (−407 to −345) | Promoter | II | 1001 | 79.95% | 772 | 81.52% | 0.006 | Additive model | 1.24; 1.01–1.51; 0.037 |
| ID | 208 | 16.61% | 163 | 17.23% | Dominant model | 1.14; 0.90–1.44; 0.281 | |||
| DD | 43 | 3.43% | 12 | 1.21% | Recessive model | 3.04; 1.64–7.05; 0.001 | |||
| D (minor) | 294 | 11.74% | 187 | 9.87% | 0.049 | ||||
| 82Gly > Ser (rs2070600) | Exon-3 | GG | 524 | 41.85% | 459 | 48.47% | 0.001 | Additive model | 1.29; 1.12–1.48; <0.001 |
| GA | 553 | 44.17% | 395 | 41.71% | Dominant model | 1.36; 1.12–1.64; 0.002 | |||
| AA | 175 | 13.98% | 93 | 9.82% | Recessive model | 1.49; 1.11–2.00; 0.008 | |||
| A (minor) | 903 | 36.06% | 581 | 30.68% | <0.001 | ||||
| 1704G > T (rs184003) | Intron-7 | GG | 638 | 50.96% | 504 | 53.22% | 0.562 | Additive model | 1.19; 0.86–1.65; 0.288 |
| GT | 535 | 42.73% | 384 | 40.55% | Dominant model | 1.18; 0.98–1.43; 0.082 | |||
| TT | 79 | 6.31% | 59 | 6.23% | Recessive model | 0.89; 0.61–1.31; 0.562 | |||
| T (minor) | 693 | 27.68% | 502 | 26.50% | 0.387 | ||||
| 2184 A > G | Intron-8 | AA | 821 | 65.58% | 620 | 65.47% | 0.115 | Additive model | 1.05; 0.90–1.23; 0.536 |
| AG | 347 | 27.72% | 282 | 29.78% | Dominant model | 0.96; 0.79–1.17; 0.693 | |||
| GG | 84 | 6.71% | 45 | 4.75% | Recessive model | 1.63; 1.08–2.46; 0.020 | |||
| G (minor) | 515 | 20.57% | 372 | 19.64% | 0.448 | ||||
Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval. Adjustment was performed for the additive, dominant and recessive models by considering age, sex, body mass index, high-density lipoprotein cholesterol, apolipoprotein-A and apolipoprotein-B.