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. 2017 Dec 4;8:991. doi: 10.3389/fphys.2017.00991

Figure 2.

Figure 2

The CaSR antagonist NPS2143 reduced IJPs evoked by L-Phe but not those evoked by L-Glu. (A,B) (left panels) show intracellular recordings of IJPs evoked by L-Phe and L-Glu. The CaSR antagonist NPS2143 (10 μM) when added to the bathing solution, reversibly reduced IJPs evoked by L-Phe (A, middle panel, histogram in C) but IJPs evoked by L-Glu were unaffected (B, middle panel, histogram in D). The histogram in (C) shows the effects of various concentrations of NPS2143 (bath applied) on the amplitudes of L-Phe evoked IJPs. NPS 2143 reversibly reduced L-Phe evoked IJPs at 10 and 30 μM, while 1 and 3 μM had no effect.