Table 5.

Amounts of D-leucine in the brain regions and serum of wild-type mice and mutant mice lacking DAO activity.

Tissues or physiological fluids	Wild-type mice (nmol/g or mL)	Mutant mice (nmol/g or mL)
Cerebrum	0.41	4.15**
Hippocampus	0.39	3.52**
Hypothalamus	0.55	4.75**
Pituitary gland	0.76	5.97**
Pineal gland	1.94a	4.91a**
Cerebellum#	0.24	5.02**
Medulla oblongata#	0.27	4.05**
Serum	0.39	10.4**

The values represent means and are obtained from ddY/DAO⁻ mice (Hamase et al., 2001).

^aValues represent pmol/whole tissues.

^#denotes tissues where DAO is present.

^**P < 0.01 compared with wild-type mice.