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. 2017 Dec 8;7:17278. doi: 10.1038/s41598-017-17677-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structure-based sequence alignment (A) of MZ0003 with 4g4g, a CE15 from M. thermophilia. Fully conserved residues are highlighted in red; residues with conserved properties are indicated in red text. Residues of the catalytic triad are indicated with green and red arrows for MZ0003 and 4g4g respectively. Loop regions identified in MZ0003 which are not conserved in fungal CE15s are boxed and indicated in yellow. (B) Overall fold of the MZ0003 monomer. Novel loop regions are colored yellow, the side chains of the catalytic residues are shown in red.