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. 2017 Dec 8;7:17236. doi: 10.1038/s41598-017-17324-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Friend virus infection leads to an increase in the number of macrophages in wild-type but not in hypoxia-inducible factor 1α knockout mice. Spleens of hypoxia-inducible factor (HIF)-1α ^+f/+f and HIF-1α ^+f/+f × LysM-Cre mice were isolated at 7 and 10 dpi, and subpopulations of spleen cells were analysed by flow cytometry. The following antibodies were used for cell population analysis: F4/80, macrophages (a); CD11b, monocytes (b); CD11c, dendritic cells (c); CD4, T helper (T_h) cells (d); CD8a, cytotoxic T lymphocytes (CTLs) (e); CD19, B cells (f). Data were obtained from 2 independent experiments and were analysed with ANOVA and Tukey’s multiple comparison test (mean + SE). n = 6–16. p-value: 0.05, ^#P = 0.05 compared to naïve mice; *P = 0.05 for wild-type (WT) mice compared with knockout (KO) mice; ns, not statistically significant.