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. 2017 Dec 8;7:17236. doi: 10.1038/s41598-017-17324-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Friend virus infection leads to activation of macrophage-stimulating 1. Spleens and livers of naïve and Friend virus (FV)-infected wild-type (WT) and knockout (KO) mice were removed 7 days after infection (dpi). Next, mRNA was isolated, and real-time polymerase chain reaction (PCR) was used to determine the expression of macrophage-stimulating 1 (MST1) in the liver (a) and MST1 receptor (MST1R) expression in the spleen (b). Proteins were isolated from spleens, and the pro-form and activated isoforms of MST1 were quantified by Western blot analysis (d). Expression of MST1 was normalised to ACTIN and is depicted in comparison to naïve control animals of the appropriate genotype (d). Data were analysed with Student’s t-test (mean + SE). n = 3. *P = 0.05.