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. 2017 Dec 8;7:17211. doi: 10.1038/s41598-017-17620-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed binding mode of fragment 3 as predicted by the MSM. The fragment is shown in green ball-and-stick representation. TSLPR is shown in grey cartoon with key residues shown in ball-and-stick. The inset shows an overlay of the TSLPR structure from our Markov state model (in grey) with the crystal structure (in violet), illustrating the lid-like opening of the loop containing Asp92.