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. 2017 Dec 8;8:1992. doi: 10.1038/s41467-017-02196-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Structure of the TF dimer in solution. a Flowchart for structural model determination of TF dimer. Structural models are indicated in orange boxes. Experimental data contributions are indicated in green boxes. Software packages are identified in purple boxes. b Lowest energy structures from the two clusters obtained with HADDOCK docking based on chemical shift perturbation data. Both monomers are represented in surface view, and one of them is semi-transparent to show the backbone. c XPLOR-NIH results represented as (I) ensemble of the 10 lowest energy structures with the flexible residue segments in gray, (II) lowest energy structures with both monomers represented in surface view, one of them depicted semi-transparent to show the backbone, and (III) lowest energy structures in surface representation with experimental PRE distances represented, intermolecular (A–B, top) and intramolecular (A–A, bottom)