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. 2017 Dec 8;7:17191. doi: 10.1038/s41598-017-17519-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between individual EXR-RLX changes in heart rate (HR) and in the BOLD response to the effort cue. On the left side, the HR changes are regressed onto the BOLD average contrast of parameter estimates in a 3mm-radius sphere centered on the global activation peak from the cueEXR-cueRLX contrast (Talairach coordinates: 8, −22, −8). On the right side, similar graphs are displayed for the anterior and posterior midcingulate clusters (aMCC, pMCC) from the whole-brain analysis. Pearson’s correlation coefficients (r) and 95% confidence intervals (CI) are indicated in the plots.