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. 2017 Dec 8;7:17262. doi: 10.1038/s41598-017-16947-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Investigation of PDIA1 and RhoGDIα co-regulation in different systems. (A) RhoGDIα protein levels following PDIA1 overexpression in VSMC using a doxycyclin-inducible lentiviral vector carrying a myc-tag; (B) Effects of PDIA1 overexpression upon RhoGDIα levels in a transgenic mouse model. Tissue from transgenic PDIA1-overexpressing mice: brain, kidney, liver, aortae and heart. Data representative of n ≥ 3, 2 (heart) or 1 (brain). (C) RhoGDIα protein and mRNA levels in VSMC from transgenic PDIA1-overexpressing mice. Representative of 3 independent experiments. Uncropped western blots are shown in Supplementary Figs S8 and S9.