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. 2017 Dec;20(12):1318–1323. doi: 10.22038/IJBMS.2017.9554

Table 1.

Antimalarial effect of different fractions of Astrodaucus persicus roots and fruits extracts against Plasmodium berghei infection in mice

Treatment Doses %Parasitemia (%Suppression)

4th Day 7th Day 14th Day 21th Day
Normal saline 0.2 ml/kg 7.70±4.13 (13.3) 19.00±6.63 (26.7) 25.60±4.72 (16.3)1 50.50±1.32 (0.0)3
RHE 500 mg/kg 1.60±1.14 (73.3)* 6.80±1.56 (64.2) 26.00±1.69 (15.4) 46.75±2.47 (9.2)3
RCL 500 mg/kg 3.70±2.49 (38.3) 8.10±1.71 (57.4) 29.87±2.21 (2.8)1 48.00±2.12 (6.8)3
REA 500 mg/kg 4.10±1.78 (31.7) 10.10±3.58 (46.8) 29.83±3.21 (3.0) ----5
RME 500 mg/kg 4.25±2.96 (29.2) 11.50±8.06 (31.2) 20.37±13.62 (33.7)1 48.00±3.94 (8.4)3
FHE 500 mg/kg 4.08±0.86 (35.3) 17.66±4.40 (39.1) 19.80±4.45 (35.2)1 47.33±1.53 (6.3)3
FCL 500 mg/kg 4.70±1.44 (25.5) 18.64±2.36 (35.7) 23.00±1.41 (24.8) 37.00±0.0 (26.7)2
FEA 500 mg/kg 1.75±1.71 (72.3)* 14.25±9.63 (50.9) 14.75±9.84 (51.7)3 39.33±9.52 (22.1)4
FME 500 mg/kg 3.13±0.68 (50.3) 20.57±4.72 (29.1) 24.08±5.37 (21.2) ----5
Chloroquine 10 mg/kg 0.00±0.00 (100) 0.00±0.00 (100) 0.00±0.00 (100) 0.00±0.00 (100)

Values are expressed as mean±SD, RHE: Root hexane fraction, RCL: root chloroform fraction, REA: Root ethyl acetate fraction, RME: Root methanol fraction, FHE: Fruit hexane fraction, FCL: Fruit chloroform fraction, FEA: Fruit ethyl acetate fraction, FME: Fruit methanol fraction.

*

There was significant difference with normal saline (P<0.05).

The superscript number means the number of died from five mice in each group.