Table 1.
Antimalarial effect of different fractions of Astrodaucus persicus roots and fruits extracts against Plasmodium berghei infection in mice
| Treatment | Doses | %Parasitemia (%Suppression) | |||
|---|---|---|---|---|---|
| 4th Day | 7th Day | 14th Day | 21th Day | ||
| Normal saline | 0.2 ml/kg | 7.70±4.13 (13.3) | 19.00±6.63 (26.7) | 25.60±4.72 (16.3)1 | 50.50±1.32 (0.0)3 |
| RHE | 500 mg/kg | 1.60±1.14 (73.3)* | 6.80±1.56 (64.2) | 26.00±1.69 (15.4) | 46.75±2.47 (9.2)3 |
| RCL | 500 mg/kg | 3.70±2.49 (38.3) | 8.10±1.71 (57.4) | 29.87±2.21 (2.8)1 | 48.00±2.12 (6.8)3 |
| REA | 500 mg/kg | 4.10±1.78 (31.7) | 10.10±3.58 (46.8) | 29.83±3.21 (3.0) | ----5 |
| RME | 500 mg/kg | 4.25±2.96 (29.2) | 11.50±8.06 (31.2) | 20.37±13.62 (33.7)1 | 48.00±3.94 (8.4)3 |
| FHE | 500 mg/kg | 4.08±0.86 (35.3) | 17.66±4.40 (39.1) | 19.80±4.45 (35.2)1 | 47.33±1.53 (6.3)3 |
| FCL | 500 mg/kg | 4.70±1.44 (25.5) | 18.64±2.36 (35.7) | 23.00±1.41 (24.8) | 37.00±0.0 (26.7)2 |
| FEA | 500 mg/kg | 1.75±1.71 (72.3)* | 14.25±9.63 (50.9) | 14.75±9.84 (51.7)3 | 39.33±9.52 (22.1)4 |
| FME | 500 mg/kg | 3.13±0.68 (50.3) | 20.57±4.72 (29.1) | 24.08±5.37 (21.2) | ----5 |
| Chloroquine | 10 mg/kg | 0.00±0.00 (100) | 0.00±0.00 (100) | 0.00±0.00 (100) | 0.00±0.00 (100) |
Values are expressed as mean±SD, RHE: Root hexane fraction, RCL: root chloroform fraction, REA: Root ethyl acetate fraction, RME: Root methanol fraction, FHE: Fruit hexane fraction, FCL: Fruit chloroform fraction, FEA: Fruit ethyl acetate fraction, FME: Fruit methanol fraction.
*
There was significant difference with normal saline (P<0.05).
The superscript number means the number of died from five mice in each group.