Table 2.
Cytotoxicity of different fractions of Astrodaucus persicus roots and fruits extracts by MTT assay
| Samples | IC50 (SI) | ||
|---|---|---|---|
| MCF7 | SW480 | L929 | |
| RHE | 0.01±0.01(70) | 0.36±0.1(1.9) | 0.70±0.12 |
| RCL | 42.21±0.48(2.4) | 71.44±0.17(1.4) | 100.00±0.93 |
| REA | 250.27±0.15(>4.0) | 397.93±0.12(>2.5) | >1000 |
| RME | >1000 | >1000 | >1000 |
| FHE | >1000 | >1000 | >1000 |
| FCL | >1000 | 5.42±1.24(>184.5) | >1000 |
| FEA | >1000 | >1000 | >1000 |
| FME | >1000 | >1000 | >1000 |
| Doxorubicin | 0.35±0.07(1.6) | 2.50±0.80(2.4) | 0.55±0.06(0.2) |
Results are expressed as IC50 value (μg/ml), mean±SD of three determinations; SI: selectivity index, MCF-7: breast adenocarcinoma, SW480: colorectal carcinoma and L929: normal cell lines., RHE: Root hexane fraction, RCL: Root chloroform fraction, REA: Root ethyl acetate fraction, RME: Root methanol fraction, FHE: Fruit hexane fraction, FCL: Fruit chloroform fraction, FEA: Fruit ethyl acetate fraction, FME: Fruit methanol fraction