Figure 4.

Effects of MMEDA on hypoxia-induced ROS generation, MDA and PGE₂ productions. BV-2 cells were treated with 1, 10, 50 µM of MMEDA for 30 min. MMEDA reduced the generation of ROS under hypoxia in BV-2 cells (A). MDA of PC12 cells were induced by 30-min hypoxia and reduced by MMEDA (B). BV-2 cells were treated with 1, 10, 50 µM of MMEDA under hypoxia 30 min. MMEDA of 10 and 50 µM, concentration-dependently reduced hypoxia-induced PGE₂ production from BV-2 cells (C). Data are expressed as mean±SEM of 3 independent experiments in triplicate. ^*: P<0.05 as compared to the hypoxia control