Table 2.

Definitions of major complication

Major complication	Definition	Comment
New-onset organ failure	New-onset failure (i.e., not present at any time in the 24 h before first intervention); Multiple-organ failure: failure of two or more organs at the same time.
Organ failure		Adapted from Bradley [24]
Pulmonary failure	PaO2 < 60 mmHg, despite FIO2of 0.30, or need for mechanical ventilation.
Circulatory failure	Circulatory systolic blood pressure < 90 mmHg, despite adequate fluid resuscitation, or need for inotropic catecholamine support.
Renal failure	Creatinine level > 177 μmol/l after rehydration or new need for hemofiltration or hemodialysis.
Systemic complication		Adapted from Bradley
Gastrointestinal bleeding	> 500 ml of blood/24 h
Intra-abdominal bleeding	Requiring surgical, radiologic, or endoscopic intervention.
Intestinal fistula	Secretion of fecal material from a percutaneous drain or inflow into the necrotic cavity, either from small or large bowel; confirmed by endscopy, imaging or during surgery.