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. 2017 Dec 4;8:968. doi: 10.3389/fphys.2017.00968

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Copyright © 2017 Pereira, Dyar, Nogara, Solagna, Marabita, Baraldo, Chemello, Germinario, Romanello, Nolte and Blaauw.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of top-ranked genes shows a significant increase in a miRNA megacluster in muscle from postnatal 2 weeks. (A) Top ranked significantly increased genes from each condition as compared to control samples. (B) Fold change (fc) of 30 miRNAs which showed at least a significant 5-fold change in expression levels in postnatal growth 2 weeks, but in no other condition. (C) Fold change of three genes expressed in the same region of the DNA as the miRNA mega cluster, namely the Dlk1-Dio3 locus (n = 4 for each group, ^*P < 0.05).