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. 2017 Dec 4;8:968. doi: 10.3389/fphys.2017.00968

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Copyright © 2017 Pereira, Dyar, Nogara, Solagna, Marabita, Baraldo, Chemello, Germinario, Romanello, Nolte and Blaauw.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Muscle growth is characterized by an increase in ribosome biogenesis and mTOR signaling. (A) Representative blot and quantification of ribosomal protein S6 phosphorylation shows a significant increase in all conditions, except for 3 weeks OL. (B) Quantification of the total amount of RNA per muscle weight. All conditions show a significant increase compared to control muscles, except for 24 h OL. (C) Representative western blots of the activation of Akt-mTOR signaling and translation initiation factors in all conditions (*P < 0.05, n = 4 per group).