Table 3.

Multivariate Cox porportional hazard model for virological relapse with off-therapy HBsAg level as a time-varying variable

Variables	Adjusted HR	95% CI	P
Time-varying HBsAg level, log IU/mL	2.10	1.45, 3.04	<0.0001
Male sex	1.33	0.58, 3.05	0.49
EOT age, year	1.04	1.02, 1.06	0.0005
EOT ALT, U/L	1.02	1.01, 1.02	<0.0001
EOT AFP, ng/mL	1.06	0.96, 1.16	0.24
EOT anti-HBe-seropositive	0.46	0.16, 1.29	0.14
Pretreatment viral DNA, log IU/mL	1.06	0.90, 1.25	0.52
Pretreatment HBeAg-positive	2.58	0.53, 12.50	0.24
Pretreatment anti-HBe-positive	4.02	0.88, 18.3	0.07

Notes. AFP alpha-fetoprotein, ALT Alanine transaminase, CI confidence interval, EOT end-of-therapy, HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HR hazard ratio