Table 4.

Multivariate Cox porportional hazard model for clinical relapse with off-therapy HBsAg level as a time-varying variable

Variables	Adjusted HR	95% CI	P
Time-varying HBsAg level, log IU/mL	2.32	1.28, 4.21	0.005
Male sex	1.05	0.33, 3.29	0.94
EOT age, year	1.03	1.00, 1.06	0.045
EOT ALT, U/L	1.03	1.02, 1.05	<0.0001
EOT AFP, ng/mL	0.88	0.67, 1.15	0.34
EOT anti-HBe-seropositive	1.27	0.14, 11.60	0.84
Pretreatment viral DNA, log IU/mL	1.03	0.79, 1.36	0.81
Pretreatment HBeAg-positive	0.46	0.66, 3.21	0.43
Pretreatment anti-HBe-positive	0.47	0.70, 3.20	0.44

Notes. AFP alpha-fetoprotein, ALT Alanine transaminase, CI confidence interval, EOT end-of-therapy, HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HR hazard ratio