Table 3.
Distribution (%) of MICs (μg/mL) | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Class | Categorya | Antimicrobial | MIC 50 | %Rb | ≤0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 |
Aminoglycoside | II | GEN | 4 | 3.4c | 4.3 | 38.6 | 50.6 | 3.0 | 3.4 | |||||
II | NEO | 8 | 49.4c | 13.7 | 36.9 | 1.3 | 48.1 | |||||||
III | SPE | 32 | 4.3 | 1.7 | 20.2 | 73.0 | 64 = 0.9 >64 = 4.3 |
|||||||
Fluorquinolone | I | ENRO | 0.12 | 3.0 | 94 | 1.3 | 1.3 | 0.4 | 3.0 | |||||
I | DANO | 0.12 | 3.9c | 91 | 4.3 | 0.9 | 3.9 | |||||||
Macrolide | II | TYLT | 32 | 99.1c | 0.4 | 0.4 | 4.3 | 94.8 | ||||||
II | TUL | 16 | 37.8 | 4.3 | 6.9 | 14.6 | 17.6 | 14.2 | 4.7 | 37.8 | ||||
II | TIL | 16 | 44.2 | 34.8 | 8.6 | 12.4 | 5.6 | 38.6 | ||||||
B lactams | I | XNL | 0.25 | 0.9 | 96.6 | 0.4 | 1.7 | 0.4 | 0.9 | |||||
II | PEN | 0.12 | 7.2 | 51.9 | 36.5 | 4.3 | 1.7 | 0.4 | 0.4 | 4.7 | ||||
II | AMP | 0.25 | 5.1c | 92.3 | 1.3 | 1.3 | 0.9 | 0.4 | 0.4 | 3.4 | ||||
Lincosamides | II | CLIN | 8 | 77.7c | 0.9 | 0.9 | 2.1 | 18.5 | 57.5 | 20.2 | ||||
Phenicol | III | FFN | 1 | 4.3 | 1.7 | 39.9 | 51.1 | 2.1 | 0.9 | 4.3 | ||||
Tetracycline | III | OXY | 8 | 53.6 | 20.6 | 20.6 | 4.3 | 0.9 | 53.6 | |||||
III | CTET | 2 | 11.2 | 8.2 | 30.0 | 25.8 | 24.9 | 11.2 | ||||||
Pleuromutilin | III | TIA | 16 | 19.7c | 0.4 | 1.7 | 3.9 | 9.4 | 64.8 | 19.7 |
Trimethoprim sulphac (Category II): <2/38 = 98.3%, >2/38 = 1.7%.
Sulphahdimethoxinec (Category III): <256 = 44.6%, >256 = 55.4%.
GEN, gentamycin/NEO, neomycin/SPE, spectinomycin; DAN, danofloxacin/ENRO, enrofloxacin; TYLT, tylosin/TUL, tulathromycin/TIL, tilmicosin; PEN, penicillin/AMP, ampicillin/XNL, ceftiofur; CLI, clindamycin; FFN, florfenicol; SXT, trimethoprim sulpha/SDM, sulphadimethoxine; OXY, oxytetracycline; CTET, chlortetracycline; TIA, tiamulin.
aCategorization of antimicrobial drugs based on importance in human medicine—Veterinary Drug Directorate.
bPathogen minimum inhibitory concentration breakpoints from CLSI standards.
cNo CLSI breakpoint for this bovine respiratory disease pathogen/antimicrobial combination, simply notes susceptibility.
Values in red indicate resistant proportion of samples.
Shaded areas indicate concentrations not tested.