Table 3.
Summary of SNPs with meta-analysis p-values ≤8.0 × 10−7
| SNP | CHR | Position | Nearest Gene | Alleles | Outcome | MOI | AA-DHSa | JHSb | Meta-Analysis | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Estimate | SE | P-value | Estimate | SE | P-value | DE | P-value | |||||||
| rs113533135 | 2 | 141,026,436 | LRP1B | T/C | CAC > =10 vs. CAC < 10 | Dominant | 0.19 | 0.05 | 1.7 × 10−4 | 0.30 | 0.08 | 3.1 × 10−4 | – | 3.3 × 10−7 |
| rs6754498 | 2 | 186,817,848 | A/G | Log(CAC + 1) | Dominant | 0.83 | 0.22 | 1.9 × 10−4 | 1.12 | 0.32 | 5.2 × 10−4 | ++ | 5.5 × 10−7 | |
| rs9973676 | 2 | 231,818,806 | GPR55 | A/G | CAC > =10 vs. CAC < 10 | Dominant | −0.20 | 0.05 | 5.8 × 10−5 | −0.22 | 0.07 | 3.1 × 10−3 | – | 6.4 × 10−7 |
| rs6898559 | 5 | 125,892,929 | ALDH7A1 | A/G | CAC > =10 vs. CAC < 10 | Additive | 0.09 | 0.03 | 4.1 × 10−4 | 0.18 | 0.04 | 4.3 × 10−5 | – | 5.0 × 10−7 |
| rs16879003 | 6 | 16,745,239 | ATXN1 | T/C | CAC > =10 vs. CAC < 10 | Additive | −0.19 | 0.04 | 7.0 × 10−6 | −0.20 | 0.07 | 4.7 × 10−3 | ++ | 1.1 × 10−7 |
| rs113805659 | 7 | 78,292,791 | MAGI2 | C/G | CAC > =10 vs. CAC < 10 | Additive | −0.19 | 0.04 | 5.5 × 10−6 | −0.21 | 0.08 | 7.5 × 10−3 | – | 1.4 × 10−7 |
| rs117854110 | 7 | 105,243,449 | T/C | Log(CAC + 1) | Dominant | −2.74 | 0.66 | 4.2 × 10−5 | −2.72 | 0.91 | 2.9 × 10−3 | – | 4.5 × 10−7 | |
| rs58071836 | 7 | 118,273,539 | T/C | CAC > =10 vs. CAC < 10 | Additive | −0.13 | 0.04 | 1.7 × 10−4 | −0.21 | 0.06 | 2.2 × 10−4 | ++ | 2.8 × 10−7 | |
| rs10978777* | 9 | 110,030,590 | C/G | Log(CAC + 1) | Additive | −0.63 | 0.16 | 1.3 × 10−4 | −0.95 | 0.24 | 8.7 × 10−5 | – | 1.2 × 10−7 | |
| rs75916004 | 11 | 101,896,887 | A/G | CAC > =10 vs. CAC < 10 | Dominant | 0.22 | 0.04 | 1.2 × 10−6 | 0.21 | 0.09 | 1.5 × 10−2 | – | 5.9 × 10−8 | |
| rs77934287 | 12 | 23,224,253 | AK094733 | A/G | CAC > =10 vs. CAC < 10 | Recessive | −0.38 | 0.10 | 3.0 × 10−4 | −0.59 | 0.16 | 1.8 × 10−4 | – | 4.8 × 10−7 |
| rs448792 | 13 | 32,677,424 | FRY | T/C | CAC > =10 vs. CAC < 10 | Dominant | 0.21 | 0.05 | 2.3 × 10−5 | 0.21 | 0.08 | 8.4 × 10−3 | ++ | 6.1 × 10−7 |
| rs77757620 | 15 | 42,953,597 | STARD9 | T/C | CAC > =10 vs. CAC < 10 | Additive | 0.15 | 0.04 | 5.0 × 10−5 | 0.18 | 0.06 | 2.3 × 10−3 | ++ | 4.3 × 10−7 |
| rs13331874 | 16 | 581,733 | SOLH | A/G | CAC > =10 vs. CAC < 10 | Recessive | −0.28 | 0.06 | 1.6 × 10−6 | −0.29 | 0.11 | 1.2 × 10−2 | ++ | 6.3 × 10−8 |
| rs4459623 | 18 | 28,798,433 | DSC1 | C/G | CAC > =10 vs. CAC < 10 | Recessive | −0.32 | 0.09 | 4.1 × 10−4 | −0.55 | 0.13 | 4.3 × 10−5 | ++ | 5.3 × 10−7 |
CHR chromosome, MOI Mode of Inheritance, DE Direction of effect (+: positive association, −: negative association)
*Upstream to ABCB1
aResults observed with the 90 HU CAC
bResults observed with the 130 HU CAC