Table 3.
Effect of different DTX formulations on A549 cells in nude mice (n=5)
| Formulations | TV (mm3)
|
Tumor weight (g) | R | IR (%) | |
|---|---|---|---|---|---|
| D0 | D10 | ||||
| Blank LPs | 126±36 | 769±84 | 0.812±0.217 | 6.103 | |
| Free DTX | 133±32 | 432±57 | 0.519±0.102 | 3.248 | 46.8 |
| DTX-LPs | 131±29 | 274±49 | 0.236±0.114 | 2.092 | 65.7 |
| TAT-DTX-LPs | 129±34 | 156±38 | 0.142±0.084 | 1.209 | 80.2 |
| RGD-DTX-LPs | 125±32 | 161±57 | 0.149±0.103 | 1.288 | 78.9 |
| TAT-RGD-DTX-LPs | 128±31 | 116±23 | 0.107±0.079 | 0.906 | 85.2 |
Abbreviations: DTX, docetaxel; LP, liposome; TV, tumor volume; R, relative tumor volume; IR, inhibitory rate.