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PRISMA flow diagram for the identification of studies included in the meta-analysis concerning the impact of LABA/LAMA FDCs on cardiovascular SAEs in COPD patients.
Abbreviations: COPD, chronic obstructive pulmonary disease; FDCs, fixed-dose combinations; LABAs, long-acting β2-agonists; LAMAs, long-acting muscarinic antagonists; PK, pharmacokinetic; RCT, randomized controlled trial; SAEs, serious adverse events.
