Table 1.
Taxol® | Abraxane® | |
---|---|---|
Formulation | Cremophor EL and dehydrated ethanol | Albumin NPs |
Particle size | N/A | ~130 nm |
MTD | 240 mg/m2 | 300 mg/m2 |
Clinical Dosage | 175 mg/m2 | 260 mg/m2 |
Administration | i.v. 3 h | i.v. 30 min |
Vd (L/m2) | 227 | 632 |
Clearance (L/h/m2) | 12.2 | 15 |
Cmax(ng/ml) | 3,650 | 18,741 |
AUC (h*ng/ml) | 15,007 | 17,434 |
t1/2 (h) | 20.2 | 27 |
All values acquired from FDA website. MTD: the maximum tolerated dose; Vd: apparent volume of distribution; Cmax: Maximum Concentration; AUC: plasma area under the curve; t1/2: half-life time. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021660s037lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf