Table 1.

Comparison of Taxol^® and Abraxane^®

	Taxol®	Abraxane®
Formulation	Cremophor EL and dehydrated ethanol	Albumin NPs
Particle size	N/A	~130 nm
MTD	240 mg/m2	300 mg/m2
Clinical Dosage	175 mg/m2	260 mg/m2
Administration	i.v. 3 h	i.v. 30 min
Vd (L/m2)	227	632
Clearance (L/h/m2)	12.2	15
Cmax(ng/ml)	3,650	18,741
AUC (h*ng/ml)	15,007	17,434
t1/2 (h)	20.2	27

All values acquired from FDA website. MTD: the maximum tolerated dose; V_d: apparent volume of distribution; C_max: Maximum Concentration; AUC: plasma area under the curve; t_1/2: half-life time. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021660s037lbl.pdf https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020262s049lbl.pdf