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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Semin Cell Dev Biol. 2017 Nov 15;72:10–18. doi: 10.1016/j.semcdb.2017.11.010

Figure 3. Protein structure of the myogenic regulatory factors.

Figure 3

Mouse amino-acid sequences of each myogenic regulatory factor were obtained from Uniprot and the phylogenetic tree was generated using Phylogeny analyzer (www.phylogeny.fr/index.cg). The phylogenetic tree reveals the close relationship between Myf5 and Myod, and myogenin and MRF4, correlating with their function during myogenesis, specification and differentiation respectively. All MRFs share highly similar and conserved bHLH domain, essential for their myogenic function. The bHLH domain is flanked by less conserved N-terminal (NH2) region containing a C/H domain and C-terminal (COOH) region containing a helix 3 domain, mediating transcriptional regulation.