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. Author manuscript; available in PMC: 2018 Dec 10.
Published in final edited form as: J Control Release. 2017 Jul 21;267:232–239. doi: 10.1016/j.jconrel.2017.07.028

Figure 5. In vivo distribution of PLGA-based NP in mouse striatum following administration via CED.

Figure 5

Representative coronal images of PLGA-PEG (red) and PLGA (green) NP infused in (A) 0.9% saline and (B) 3% saline. Data represent the average of N ≥ 3 mouse brain specimen for each condition. (C) Quantified Vd of PLGA-PEG and PLGA NP in mouse striatum. Inset depicts the amplified view of PLGA Vd. *p < 0.05 denotes statistical significant difference. High magnification images of PLGA-PEG NP near lateral striate arteries following infusion in (D) 0.9% saline and (E) 3% saline. Blue indicates cell nuclei (DAPI). (F) Relative distribution of NP in PVS away from the striate arteries. (G) Percent coverage of PLGA-PEG NP fluorescence within the brain ICS calculated using image-based MATLAB quantification. Statistical significant difference is denoted by *p < 0.05.