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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Thromb Res. 2017 Oct 26;160:58–65. doi: 10.1016/j.thromres.2017.10.018

Figure 1. Townes sickle mice display thrombocytopenia and platelet activation.

Figure 1

Whole blood collected from AA, SS, and SSCKO mice (n = 6 – 9 per genotype) was evaluated for platelet counts using flow cytometry (A). Expression of platelet surface activated GPIIb-IIIa reported as mean fluorescent intensity (per cell) of activated GPIIb-IIIa (B), and percentage of platelets positive for activated GPIIb-IIIa (C) is shown. Data in (B) and (C) were normalized to percent of maximal activation induced by TGPRP. All data are presented as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001. Abbreviations: MFI = mean fluorescence intensity; ADP = Adenosine 5’-diphosphate (20 µM), TGPRP = Thrombin Gly-Pro-Arg-Pro (2U/mL).