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. Author manuscript; available in PMC: 2018 Mar 28.
Published in final edited form as: J Labelled Comp Radiopharm. 2017 Jul 25;61(3):252–262. doi: 10.1002/jlcr.3528

Figure 5.

Figure 5

General “in-loop” [11C]CO2-fixation radiosynthesis procedure. Step 1: The “in-loop” [11C]CO2 fixation in a pre-loaded trapping-solution (BEMP, amine dissolved in DMF) to form the intermediate product, [11C]carbamate ion (reactor loop, section A). Step 2: Elution and “in-loop” reaction using a pre-loaded solution (POCl3 or methyl iodide in reagent loop) in section A of the reactor loop, followed by a second in-loop reaction with a pre-loaded nucleophile (alcohol or amine) in section B of the reactor loop.