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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Clin Pharmacol Ther. 2017 Oct 10;103(4):599–618. doi: 10.1002/cpt.762

Figure 2. Phenotype translation and nortriptyline dose recommendations of the CPIC and DPWG based on CYP2D6 activity scores.

Figure 2

Solid bars: CPIC interpretation of phenotype and dosing recommendation. Hatched bars: DPWG interpretation of phenotype and dosing recommendation. Red: poor metabolizer, Orange: intermediate metabolizer, Green: normal metabolizer, Blue: ultra-rapid metabolizer. Note: CPIC provides no specific dose adjustment for amitriptyline but recommends to consider increasing the dose and using therapeutic drug monitoring to guide dose adjustments.