. Author manuscript; available in PMC: 2019 Apr 1.

Published in final edited form as: Clin Pharmacol Ther. 2017 Oct 10;103(4):599–618. doi: 10.1002/cpt.762

Table 2.

Discordances in terminology for allele function and phenotypes

Category	Functional definition	Consortium	Term
Allele	Greater than normal function	CPIC	Increased function
Allele	Greater than normal function	DPWG	Gain-of-function^*
Allele	Less than normal function	CPIC	Decreased function
Allele	Less than normal function	DPWG	Decreased activity^*
Phenotype	Individuals who carry two alleles which encode for a fully functional enzyme or individuals with a combination of an allele which encodes for a fully functional enzyme and an allele which encodes for an enzyme with decreased function	CPIC	Normal metabolizer
Phenotype		DPWG	Extensive metabolizer^*
Phenotype	An individual carrying one normal function allele and one increased function allele	CPIC	Rapid metabolizer
Phenotype		DPWG	-

In this article the terminology of the CPIC will be used.