. Author manuscript; available in PMC: 2019 Apr 1.

Published in final edited form as: Clin Pharmacol Ther. 2017 Oct 10;103(4):599–618. doi: 10.1002/cpt.762

Table 3.

Discordances in genotype to phenotype translation

Gene	Genotype / activity score	Classification^*
CYP2C19	1/17	CPIC: Rapid metabolizer	(24;26;44–50)
CYP2C19	1/17	DPWG: Normal metabolizer	(5;6;44–50)
CYP2D6	AS 1.0	CPIC: Normal metabolizer	(15;16)
CYP2D6	AS 1.0	DPWG: Intermediate metabolizer	(57)
CYP2D6	AS 2.5	CPIC: Ultra-rapid metabolizer	(15;16)
CYP2D6	AS 2.5	DPWG: Normal metabolizer	(7)
DPYD	2846AT / 1236GA	CPIC: Normal metabolizer	(14)
DPYD	2846AT / 1236GA	DPWG: AS 1.5 / Intermediate metabolizer	(7;14;51)
DPYD	e.g. (*2A + (2846AT or 1236GA))	CPIC: Intermediate metabolizer	(14)
DPYD	e.g. (*2A + (2846AT or 1236GA))	DPWG: AS 0.5 / Intermediate metabolizer	(7;14;51)

As a result of a consensus in a CPIC project to standardize terms for PGx test results the CPIC has adopted the term normal metabolizer to replace the historical term extensive metabolizer as experts participating in the CPIC project found it less confusing for clinicians. In this comparison the term normal metabolizer is used (See Table 2) (38).