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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Brain Imaging Behav. 2019 Feb;13(1):41–52. doi: 10.1007/s11682-017-9732-9

Figure 2. Predicted associations between baseline CSF biomarker levels of p-tau/Aβ42 and YKL-40 and longitudinally-measured white matter mean diffusivity.

Figure 2

Top panel: higher p-tau/Aβ42 levels were associated with higher MD at baseline (intercept) but not change over time (slopes are not significantly different from zero) in the cingulum bundle adjacent to the corpus callosum. Bottom panel: higher YKL-40 levels were associated with increasing MD over time (slope) but were not associated with baseline MD (intercept). Although the CSF variables were analyzed as continuous predictors, for visualization purposes they are displayed as high (CSF levels >1 SD above the mean, dashed line), mean (CSF levels within 1 SD of the mean, dotted line), and low (CSF levels >1 SD below the mean, solid line). Y-axis: Mean Diffusivity (MD) in the specified ROI. X-axis: Time operationalized as interval from baseline MRI in years. 95% Confidence Intervals (C.I.’s) are displayed by the gray shaded regions.