Table 1.
Sample characteristics
| Sample Characteristics | N | Mean/Frequency | SD | Range |
|---|---|---|---|---|
| Age at baseline MRI | 151 | 60.3 | 6.4 | 44.1 to 79.1 |
| Sex (% female) | 151 | 68.6% | ||
| APOE ε4 carriage | 151 | 37.3% | ||
| Baseline MRI to LP interval (months) | 151 | 4.34 | 12.61 | −35 to 45 |
| Interval between LPs (months) | 91 | 25.1 | 4.8 | 8 – 40 |
| CSF p-tau/Aβ42 | 149 | 0.061 | 0.027 | 0.0236 – 0.186 |
| CSF Neurogranin | 146 | 387.29 | 177.97 | 125.00 – 957.84 |
| CSF YKL-40 | 151 | 145033.88 | 51388.87 | 49994.00 – 335820.87 |
| CSF NFL | 150 | 625.25 | 243.15 | 222.00 – 2030.00 |
| ΔCSF p-tau/Aβ42 | 89 | 0.007 | 0.016 | −0.037 – 0.060 |
| ΔCSF Neurogranin | 86 | 32.75 | 118.84 | −417.93 – 657.13 |
| ΔCSF YKL-40 | 91 | 11025.99 | 21155.65 | −41812.00 – 99199.11 |
| ΔCSF NFL | 89 | 80.510 | 207.76 | −984.00 – 1070.00 |
All CSF values are in ng/L. N’s varied due to assay sensitivity/variability. APOE=apolipoprotein; MRI=Magnetic Resonance Imaging; LP=lumbar puncture; CSF=cerebrospinal fluid; p-tau/Aβ42=phosphorylated-tau to beta-amyloid-42 ratio; YKL-40= chitinase-3-like protein; NFL=neurofilament light protein; SD=standard deviation.