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. 2017 Nov 27;15:41–50. doi: 10.1016/j.redox.2017.11.022

Fig. 4.

Fig. 4

The levels of lipid peroxidation products [4-HNE, MDA, 8-isoPGF2 and NPs] as well as the levels of oxidative modification products of protein [CO and Trp] and DNA [8-OH dG] in the kidney of hypertensive rats (A-SHR; B-DOCA-salt) and hypertensive rats after the administration of URB597. A. Data points represent the mean ± SD, n = 6; (a, significantly different from WKY group, p < 0.05; b, significantly different from SHR group, p < 0.05). B. Data points represent the mean ± SD; n = 6; (a, significantly different from Wistar group, p < 0.05); b, significantly different from DOCA-salt group, p < 0.05). The results are shown in comparison to the control groups [WKY rats and Wistar rats]: aldehydes concentrations (4-HNE: 691 ± 32 nmol/g tissue for WKY rats, 133 ± 6 nmol/g tissue for Wistar rats; MDA: 146 ± 8 nmol/g tissue for WKY rats, 29.7 ± 1.4 nmol/g tissue for Wistar rats); 8-isoPGF2α level (56.6 ± 2.7 ng/g tissue for WKY rats, 34.3 ± 1.5 ng/g tissue for Wistar rats); A4/J4-NPs concentrations (25.8 ± 1.1 ng/g tissue for WKY rats, 8.94 ± 0.46 ng/g tissue for Wistar rats); carbonyl groups level (3.26 ± 1.1 nmol/mg prot. for WKY rats, 6.66 ± 0.19 nmol/mg prot. for Wistar rats); tryptophan level (20.7 ± 1.1 U/mg prot. for WKY rats, 20.01 ± 1.10 U/mg prot. for Wistar rats); 8-OHdG level (10.8 ± 0.6 ng/mg DNA for WKY rats, 4.98 ± 0.22 ng/mg DNA for Wistar rats).