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NoxO1 and p47phox do not contribute to disease onset but to endothelial dysfunction induced by diabetes. A: blood glucose concentration during STZ-induced diabetes (70 mg/kg/day). B: body weight loss over diabetes. C-E: organ bath experiments of mesenteric vessel pre-constricted with phenylephrine and relaxed with acetylcholine. n ≥ 8, black circles: WT CTR and black squares: WT +STZ. * p < 0.05 wt vs. WT +STZ, # p < 0.05 wt +STZ vs. p47-/- +STZ, + p < 0.05 wt +STZ vs. O1/47-/- +STZ.
