Table 1.
Baseline characteristics of patients and controls.
| Subject | Age/years | Scans | ALS-FRS-R | Site of onset | Time from diagnosis to baseline MRI (months) | Time from first symptom to baseline MRI (months) | ALS-FRS-R rate of decline/(% per year) | Duration of follow-up |
|---|---|---|---|---|---|---|---|---|
| ALS 01 | 40–50 | 5 | 48 | R LE | 2 | 8 | 13 | 15 |
| ALS 02 | 60–70 | 3 | 41 | L UE | 5 | 12 | 25 | 9 |
| ALS 03 | 50–60 | 6 | 44 | L LE | 1 | 14 | 21 | 20 |
| ALS 04 | 20–30 | 15 | 26 | L UE | 14 | 23 | 5 | 48 |
| ALS 05 | 20–30 | 9 | 45 | L UE | 2 | 8 | 13 | 36 |
| ALS 06 | 40–50 | 8 | 44 | R LE | 4 | 41 | 10 | 27 |
| control 01 | 30–40 | 5 | na | na | na | na | na | 35 |
| control 02 | 30–40 | 4 | na | na | na | na | na | 27 |
| control 03 | 20–30 | 3 | na | na | na | na | na | 24 |
| control 04 | 50–60 | 2 | na | na | na | na | na | 5 |
| control 05 | 40–50 | 2 | na | na | na | na | na | 4 |
| control 06 | 50–60 | 2 | na | na | na | na | na | 4 |
| p (t-test) | 0.7 | na | na | na | na | na | na | 0.3 |
ALS, amyotrophic lateral sclerosis; m, male; f, female; ALSFRS-R, ALS Functional Rating Scale Revised; R LE, right lower extremity; L LE, left lower extremity; R UE, right upper extremity; L UE, left upper extremity; MRI, magnetic resonance imaging, time from diagnosis was obtained according to the referral letter or own diagnostics, the patient ware asked about the time of first symptoms.