Table 3.

Arithmetically averaged progression rates (in %/year) for ALS patients and controls (mean ± standard deviation) for DTI metrics—axial diffusivity (AD), fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and AD/RD.

Progression rates (in %/year)	ALS patients	Range (ALS patients)	Controls	Range (controls)	Correlation to ALS-FRS-R progression
FA (decrease)	2.6 ± 2.2	0.2–5.6	0.3 ± 0.2	0.0–0.5	0.98 (p = 0.0008*)
MD (increase)	−1.9 ± 1.5	−4.6 to −0.6	−0.08 ± 0.05	−0.2 to 0.0	−0.65 (p = 0.2)
AD (increase)	−2.0 ± 2.2	−6.2 to −0.2	−0.1 ± 0.6	−0.8 to 0.6	−0.47 (p = 0.3)
RD (increase)	−2.2 ± 1.2	−4.3 to −1.2	−0.1 ± 0.8	−1.0 to 1.0	−0.66 (p = 0.2)
AD/RD (decrease)	6.1 ± 3.7	1.6–12.3	0.4 ± 0.3	0.0–0.7	0.97 (p = 0.0011*)
ALS-FRS-R (decrease)	14 ± 7	6–25	n.a.	n.a.	n.a.

*Significant correlation.