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. 2017 Dec 5;8:1687. doi: 10.3389/fimmu.2017.01687

Table 2.

Summary table with information about the variants that reside in genes with more than one associated variant.

Single nucleotide polymorphism Chr Position Ref Alt GeneName GeneFunction AF_all AF_afr AF_eur Diff_AMR Diff_CMR Diff_NoRej p-Value eGenes—blood vessels eGenes—whole blood
rs2072306 19 2109019 T C AP3D1 (kidney, blood vessels, cell-surface) Intronic 0.33 0.49 0.20 11 0 1 4.73E−04 AP3D1 AP3D1
rs20567 19 2110746 G A Exonic-synonymous 0.33 0.49 0.20 11 0 1 4.73E−04 AP3D1 AP3D1
rs2074959 19 2111649 T C Intronic 0.33 0.49 0.20 11 0 1 4.73E−04 AP3D1 AP3D1
rs2066775 19 2115493 A G Intronic 0.33 0.49 0.20 11 0 1 4.73E−04 AP3D1 AP3D1
rs4807203 19 2127272 A G Intronic 0.34 0.54 0.20 11 0 1 4.73E−04 AP3D1 AP3D1
rs2271804 10 12252217 G A CDC123 Intronic 0.38 0.19 0.52 11 2 0 8.08E−04 CAMK1D
rs10951 10 12292344 A G UTR3 0.65 0.73 0.60 13 3 1 9.08E−04 CDC123 CAMK1D
rs9940301 16 80641906 G A CDYL2 Intronic 0.38 0.76 0.23 13 1 3 9.08E−04
rs9933302 16 80641931 T C Intronic 0.41 0.84 0.23 13 1 3 9.08E−04
rs55980973 8 113655644 A T CSMD3 (cell-surface) Intronic 0.56 0.81 0.44 12 4 0 6.82E−04
rs6992564 8 113662299 T G Intronic 0.56 0.81 0.44 12 4 0 6.82E−04
rs7839990 8 113697567 A G Intronic 0.56 0.78 0.45 12 5 0 3.51E−04
rs2243558 9 130289615 C G FAM129B (kidney, blood vessels) Intronic 0.58 0.59 0.68 14 1 2 1.70E−05 ZNF79, RPL12 SLC2A8, ZNF79, RPL12
rs2251409 9 130286150 A G Intronic 0.57 0.60 0.68 14 2 2 1.77E−04 ZNF79, RPL12 SLC2A8, ZNF79, RPL12
rs13264965 8 79672953 A G IL7 (immune, cell-surface) Intronic 11 2 0 8.08E−04
rs4739138 8 79673952 T C Intronic 0.21 0.34 0.07 11 2 0 8.08E−04
rs78118592 7 100550837 C T MUC3A Exonic-nonsynonymous 0.06 0.05 0.10 13 1 4 8.73E−04
rs200242471 7 100550841 C A Exonic-synonymous 13 1 4 8.73E−04
rs3817699 8 2024437 C T MYOM2 Intronic 0.64 0.89 0.57 12 0 6 2.74E−04
rs3817700 8 2024446 C T Intronic 0.64 0.89 0.56 12 0 6 2.74E−04
rs1030723 11 4790471 G A OR51F1(cell-surface) Exonic-nonsynonymous 0.17 0.44 0.13 11 2 0 8.08E−04
rs11033793 11 4790474 T C Exonic-nonsynonymous 0.17 0.44 0.13 11 2 0 8.08E−04
rs10836609 11 4791178 C A Upstream 0.12 0.28 0.13 11 2 0 8.08E−04
rs10836610 11 4791181 T G Upstream 0.12 0.28 0.13 11 2 0 8.08E−04
rs4268525 11 124121199 G C OR8G1 (cell-surface) Exonic-unknown 0.44 0.32 0.55 13 3 1 9.08E−04 VWA5A
rs2466636 11 124134552 C T Intronic 0.44 0.29 0.55 13 3 1 9.08E−04 VWA5A
rs2512168 11 124135009 G A OR8G5 (cell-surface) Exonic-nonsynonymous 0.44 0.29 0.55 13 3 1 9.08E−04 VWA5A
rs2512167 11 124135438 G A Exonic-nonsynonymous 0.44 0.29 0.55 13 3 1 9.08E−04 VWA5A
rs2466701 11 124135481 C T Exonic-synonymous 0.44 0.29 0.55 13 3 1 9.08E−04 VWA5A
rs577219 19 7615585 T G PNPLA6 Intronic 0.67 0.57 0.72 12 1 0 5.05E−05
rs574663 19 7614677 C T Intronic 0.67 0.55 0.72 11 1 0 4.73E−04
rs11405 1 227069677 T C PSEN2 (immune, cell-surface) Exonic-synonymous 0.74 0.83 0.80 12 2 0 2.00E−04
rs2236910 1 227073410 G C Intronic 0.74 0.83 0.80 12 2 0 2.00E−04
rs2802267 1 227078955 T C Intronic 0.72 0.78 0.80 11 2 0 8.08E−04
rs10753428 1 227081622 A G Intronic 0.70 0.80 0.80 12 2 0 8.08E−04
rs4074317 13 114747187 G C RASA3 Downstream 0.65 0.64 0.74 9 7 0 1.70E−04
rs2274716 13 114781868 G A Intronic 0.35 0.35 0.27 9 7 0 1.70E−04
rs12706498 7 122788665 G A SLC13A1 Intronic 0.21 0.06 0.30 11 2 0 8.08E−04
rs3734518 6 74304415 G C SLC17A5 UTR3 0.17 0.21 0.30 13 0 3 3.82E−05 MTO1
rs3803956 20 3214581 C T SLC4A11 Exonic-synonymous 0.17 0.22 0.18 12 3 0 3.99E−04 ITPA ITPA, C20orf194
rs12737742 1 110709720 G A SLC6A17 Exonic-nonsynonymous 0.25 0.03 0.47 12 5 0 3.51E−04
rs1061040 14 23242828 T C SLC7A7 (kidney, cell-surface) Exonic-synonymous 0.79 0.45 0.90 12 1 0 5.05E−05
rs28620278 15 56959028 C T ZNF280D Exonic-nonsynonymous 0.53 0.71 0.41 14 3 1 4.27E−05
rs12911191 15 56961272 T A Intronic 0.46 0.28 0.59 13 4 1 8.73E−04
rs12562454 1 26671084 G T AIM1L (cell-surface) Exonic-nonsynonymous 0.18 0.15 0.19 3 7 0 1.43E−04
rs57268417 1 26671248 A G Exonic-nonsynonymous 0.18 0.15 0.19 3 7 0 1.43E−04
rs11247924 1 26673076 G A Exonic-nonsynonymous 0.18 0.15 0.19 3 7 0 1.43E−04
rs11247925 1 26673108 C T Exonic-nonsynonymous 0.18 0.15 0.19 3 7 0 1.43E−04
rs2231547 11 3687626 T G CHRNA10 (cell-surface) Exonic-nonsynonymous 0.02 0.00 0.07 0 5 1 8.18E−04
rs2231546 11 3687651 C T Exonic-nonsynonymous 0.02 0.00 0.07 0 5 1 8.18E−04
rs41282822 20 36869396 G A KIAA1755 (blood vessels) Exonic-synonymous 0.03 0.07 0.02 1 6 1 9.59E−04
rs41282824 20 36869769 C T Exonic-nonsynonymous 0.03 0.07 0.02 1 6 1 9.59E−04
rs112586932 20 36874313 G T Intronic 0.02 0.03 0.02 0 5 1 8.18E−04

AF_all, AF_afr, and AF_eur show the allele frequency in all populations, African population, and European population, respectively.

Diff_AMR, Diff_CMR, and Diff_NoRej show the number of pairs that are mismatched for antibody-mediated rejection (AMR), T-cell-mediated rejection (CMR), and no-rejection (NoRej), respectively.