Alagebrium (ALT7-11) |
AGE cross-link breaker |
Aldose reductase inhibitors (ARI) |
Blockade of Aldose Reductase on glucose metabolism that contributes to AGE formation |
Aminoguanidine |
Blockade of AGE production |
Azeliragon |
Small molecule inhibitor of RAGE ligand binding to the RAGE extracellular V-domain |
Anti-RAGE antibodies |
Blockade of ligand binding to RAGE |
Inhibitors of RAGE tail-DIAPH1 binding |
Blockade of RAGE signal transduction |
Upregulation/Activation of glyoxalase-1 |
Augmentation of detoxification of AGE precursors |
Soluble RAGE (sRAGE) or Endogenous secretory RAGE (esRAGE) |
RAGE ligand binding species that sequester RAGE ligands and block their biological effects |
Vitamin C, Vitamin E |
Anti-oxidants, possible effects on reduction of AGE formation and AGE effects |