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. 2017 Dec 5;8:1717. doi: 10.3389/fimmu.2017.01717

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Copyright © 2017 Dumont-Lagacé, Gerbe, Daouda, Laverdure, Brochu, Lemieux, Gagnon and Perreault.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Most label-retaining cells (LRCs) are K5⁺K8⁺ and localized near the cortico-medullary junction. (A) Representative images of thymic slices after 16 weeks of chase in control (H2B-GFP⁺ WT, left panels) and test mice (H2B-GFP⁺ rtTA, right panels). (B) Representative images of K5⁺K8⁺ GFP^hi cells. Cytokeratin K5 is shown in red, K8 in blue, and histone 2B-GFP fusion protein (H2B-GFP) in green. (C) Quantification of LRCs expressing K5, K8, or both cytokeratins. The number of LRCs per thymic lobe (green) from each TEC subset is compared with the surface area (blue) covered by this subset. (D) Percentage of LRCs found in different regions of the thymus. The proportions of LRCs are significantly higher in the cortico-medullary region (CMR) than the cortex or the medulla (n = 4).