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. 2017 Dec 5;8:1717. doi: 10.3389/fimmu.2017.01717

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Copyright © 2017 Dumont-Lagacé, Gerbe, Daouda, Laverdure, Brochu, Lemieux, Gagnon and Perreault.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UEA1^– NonLRCs are well adapted to communicate with hematopoietic cells. (A) REViGO graphical representation of significant gene ontology (GO)-term enrichment for genes expressed at higher level in UEA1^– NonLRCs than UEA1^– label-retaining cells (LRCs). The position of GO-terms represents their semantic similarities calculated by REViGO, the size represents the mean enrichment score of the GO-terms contained in each point, and the color indicates the p value for that particular GO-term. (B) Heatmap showing the differential expression of genes involved in GO-terms related to interactions with hematopoietic cells. All GO-terms are determined using DAVID online bioinformatic gene enrichment tool from the top 500 genes expressed at higher level in UEA1^– NonLRCs than UEA1^– LRCs. Semantic relations between GO-terms of interest are shown below, and the number of genes per GO-term is shown in parentheses.